Leather and Glitter

So you don’t waste your money and annoy your budtenders…those of you who want to benefit from treatment rather than dab, breakdown below.

Cannabinoids: biological
compounds that bind to cannabinoid receptors

Cannabinoid
receptors: adjust the activity of whichever bodily system needs to be adjusted,
whether that is hunger, temperature, or alertness

Phytocannabinoids:
cannabinoids that occur naturally in the cannabis plant

Endocannabinoids:
naturally occurring lipid-based neurotransmitters found in body; send signals
between nerve cells. Endocannabinoids help with various bodily functions; the
“Locks” that the phytocannabinoids “key” to “unlock”; the receptor is the lock
and the cannabinoid molecule is the key – when the cannabinoid
“key” attaches to the receptor “lock”, which is on the cell wall, a reaction is
triggered resulting in an effect on the brain and body

Endocannabinoid
system (ECS):  helps the body maintain homeostasis through its
three main components: “messenger” molecules called cannabinoids, the receptors
that these molecules bind to, and the enzymes that break them down for the body
to synthesize. Pain, stress, appetite, energy, metabolism, cardiovascular
function, reward and motivation, reproduction, and sleep are all functions that
the ECS can modulate

Anandamide: the
first endocannabinoid (inside the body) to be discovered; a neurotransmitter
that binds to cannabinoid receptors in brain and body, stimulating a sense of
happiness and well-being

Entourage effect:
the effect felt by combining cannabinoids usually good for therapeutic effect
and more potent high; the way the unique “high” is felt by combining
cannabinoids & terpenes

Broad spectrum: a product that has many of the active ingredients found in
cannabis, but has specifically had the THC removed, ensuring a clear urine drug
screen while still delivering multiple beneficial molecules (ie Broad Spectrum
CBD)

Full Spectrum:  term applied to a wide variety of products
that is meant to express that the product represents all of the molecules found
in the cannabis it was made from; contains cannabinoids, terpenes, and
sometimes even additional plant lipids-said to be most potent form of cannabis

Rick Simpson Oil
(RSO)/Full Spectrum Oil (FSO): crude oil given to cancer patients; contains all
the cannabinoids, terpenes, and additional compounds of the whole cannabis
plant

Isolate: Isolate is
used to describe any product that only contains one purified cannabis
constituent (ie CBG isolate); may be helpful for those looking for a very
consistent product or those who need assurances that a certain product will not
cause a positive drug screen

Decarboxylation: a process that actives the
psychoactive compounds in the cannabis plant so that you feel high
when you consume it

CB1 Receptors: CB1 stands for
“cannabinoid receptor type 1”; CB1 is expressed primarily in the brain, central
nervous system, lungs, liver, and kidneys; THC makes you feel high by
activating your body’s CB1 receptors

CB2 Receptors: CB2 is expressed
primarily in your immune system

CBC:
cannabichromene // studies show good for inflammation; anti cancer properties;
gastrointestinal aid; mostly works on CB2

CBG: cannabigerol
// “mother of all cannabinoids;” inhibits certain cancer proliferation in
certain studies; antibacterial; anti-inflammatory; binds directly to both CB1 and
CB2 receptors and might deliver its benefits to the system more efficiently

CBGA:
acid form of CBG (cannabigerolic acid); breaks down and converts into THCA and CBDA

CBD: cannabidiol // anxiety, inflammation, staying asleep; interacts with CB1 and
CB2 receptors

CBDA: acid form of CBD (hasn’t been decarboxylated yet)

THC: tetrahydrocannabinol // the “high” cannabinoid in the cannabis plant;
acute pain, falling asleep, euphoria; can interact with CB1 and CB2

THCA: acid form of THC (non psychoactive though some users report intoxicating
effects); hasn’t been decarboxylated

THCV: appetite suppressant; antagonizes CB1 effects of THC, works on CB2

CBN: cannabinol // mildly psychoactive cannabinoid that acts as a low affinity
partial agonist at both CB1 and CB2 receptors; sleep
cycle, thought to be light degraded THC, also helps nerve pain

Delta
9 THC: Delta-9
THC is the most common and well-studied form of THC

Delta
8 THC: cannabis compound that has become popular because of its similarity to
delta-9 THC, the main compound in cannabis that gets you high, causing
euphoria, happiness, sedation, symptom relief, and much more

11
Hydroxy THC: When you eat a product containing THC, your liver will process the
THC and convert it into 11-hydroxy-THC. 11-hydroxy-THC (11-OH-THC) is the main
active metabolite of THC

Tincture:
oil or liquid version of cannabis made to be drank or taken sublingually

Sublingual:
taken under the tongue and absorbed through arteries in the mouth (delta 9
taken like this will stay delta 9, not convert to 11-Hydroxy THC like edibles)

Transdermal
patch effect time: 8-12 hours of relief

Bioavailability: proportion of a drug or substance that enters your circulation
when introduced to the body, then has an active effect

Edibles
bioavailability: 6-10%

Sublinguals bioavailiability: 10-15%

Inhalables bioavailability: 15-20%

Topical cannabis: limited reach, applied to skin only, supposed to never cause
positive drug testTransdermal
cannabis (“trans” – across, “derm” – skin): has psychoactive effects; can cause
failed THC test